Wasps will be hoping for a better than campaign than the last where they lost their four final fixtures of the season, although they'll take comfort in the fact that they are unbeaten in the last 3 London Double Headers. Dai Young's new signings Andrea Masi, Fabio Staibano and James Haskell all start with Tom Palmer, T Rhys Thomas and Ashley Johnson named on their bench.
The champions will be captained by England skipper Chris Robshaw with Nick Evans making his 100th appearance for Quins. It is the same pack that started the 2011-12 Premiership final while Danny Care starts alongside Evans at half-back with George Lowe shifting to the wing with Ugo Monye absent. And Robshaw is hoping to draw inspiration from the Olympics throughout this campaign.
Saturday's second match at Twickenham sees Saracens tackle London Irish and Sarries have handed a debut to England winger Chris Ashton. Schalk Brits and Kelly Brown make their return from injury while rugby league convert Joel Tomkins gets the nod at outside centre alongside Brad Barritt.
The Exiles have also handed starts to some of their new signings: Tomas O'Leary, Scott Lawson and George Skivington. England centre Jonathan Joseph lines up alongside Sailosi Tagicakibau in the midfield while Steve Shingler starts at fly-half alongside O'Leary. Second-row Bryn Evans captains the side with club captain Declan Danaher on the bench with new faces Shane Geraghty and Cai Griffiths joining him.
Elsewhere, star signing Danny Cipriani will have to wait for his first Sale Sharks start with Bryan Redpath opting to name him among their replacements for their trip to the Exeter Chiefs. But while Cipriani is benched, Richie Gray is handed a start with fellow new signings Eifion Lewis-Roberts and Corne Uys also getting the nod.
Exeter have also bolstered their squad in the off-season with eight new recruits but only two of them start against the Sharks - Will Chudley and Ian Whitten. Tom Hayes skippers the side in the second-row with Tom Johnson and James Scaysbrook starting in their back-row.
Gloucester have also opted to blood some of their new recruits for their match at Kingsholm with the Northampton Saints. Billy Twelvetrees starts alongside Mike Tindall in the centres with Ben Morgan packing down at the back of their scrum with Alex Brown captaining the side from the second-row. Huia Edmonds and Martyn Thomas will have to be content with a spot amongst the replacements.
For the Saints, Ken Pisi starts on the wing with other new signings Dom Waldouck and GJ van Velze also playing. Dylan Hartley captains the team with Rhys Oakley and Luther Burrell named on the bench. And one other notable inclusion is England flanker Tom Wood who endured an injury plagued 2011-12 season.
Saturday's action will be completed by Worcester Warriors' match with Bath at Sixways. Richard Hill has made a raft of signings in both his backroom staff and on the pitch and one of these - Dean Schofield - captains the team. He is one of five preparing to take their Warriors bow with Semisi Taulava, John Andress, David Lemi and Josh Matavesi also starting. Three of Bath's players will make their first start in the Premiership for the West Country side with Kyle Eastmond, Dominic Day and Paul James all getting the nod. Olly Barkley starts at fly-half with Francois Louw named at openside despite his recent Springboks call up.
And on Sunday, the Premiership will get their first glimpse of London Welsh as they take on the Leicester Tigers at the Kassam Stadium. It will be a baptism of fire for many of the Exiles and they have named new signings Tom Arscott, Phil Mackenzie, Sonny Parker, Franck Montanella, Neil Briggs, Paulica Ion, Kirill Kulemin, Ed Williamson and Dan Browne in their starting XV.
Two of the Tigers will also pull on the Leicester shirt for the first time in the top-flight with Vereniki Goneva named on the wing and Rob Andrew in the second-row. Toby Flood starts at fly-half alongside Micky Young while Tom Youngs gets the nod at hooker ahead of George Chuter.
Keep up to date with all the action from Exeter Chiefs vs Sale Sharks on the @SaleSharksRugby Twitter account.
Tickets are available for the exciting Round 2 clash when the Sale Sharks take on Saracens in the North West team's first Aviva Premiership match at their new ground, Salford City Stadium, on Saturday 8th September at 4.30pm. Tickets can be purchased online on the Sale Sharks tickets page. Fans can also email their details to email@example.com and our ticketing staff will call you back on Monday to process your tickets. Tickets can also be purchased over the phone by calling 08444 994 994.
Although the game kicks off at 4.30pm, there will entertainment and drinks offers from 2.30pm at the stadium, including the chance to meet the non-playing squad. So, book your tickets today, enjoy Round 1 and then look forward to a great day at Salford City Stadium on September 8th.