Media reports from Northampton indicate that George Pisi, Dylan Hartley and former Sharks favourite Ben Foden are available for selection for a game which is crucial to both teams, for different reasons.
For information getting to Friday night's game, have a look at our travel plan.
Friday 30th November
Harlequins v Worcester Warriors (Twickenham Stoop, 7.45pm)
Sale Sharks v Northampton Saints (Salford City Stadium, 7.45pm)
Saturday 1st December
Leicester Tigers v Bath Rugby (Welford Road, 12.30pm)
London Welsh v London Irish (Kassam Stadium, 1pm)
Exeter Chiefs v London Wasps (Sandy Park, 5.30pm)
Sunday 2nd December
Saracens v Gloucester Rugby (Vicarage Road, 3pm)
Referee: Luke Pearce
Harlequins' six game winning run in all competitions ended at Bath on Friday. The reigning Aviva Premiership Rugby champions still top the table despite winning just two of their last five games in the competition. Quins only defeat at the Twickenham Stoop this season came to Saracens,16-18, on 30th September.
Worcester Warriors last six encounters in the Premiership have all been won by the home side on the day, whilst Worcester's solo away victory since New Year's Day came in Spain against Gernika on 13th October.
Harlequins have won their last nine fixtures with the Warriors in all competitions. Worcester have won just once at the Stoop in the Premiership: 15-9 on 19th February 2005.
Referee: Llyr ApGeraint Roberts
Sale Sharks' solitary victory in their last ten Aviva Premiership Rugby encounters was 21-9 at home to London Irish on 2nd November. Sale have won their last three games at Salford City Stadium in all competitions.
Northampton Saints have won their last two games against Newport Gwent Dragons and London Welsh, whilst the Saints have lost their last two away games in the Premiership.
The Sharks have won just one of their last seven clashes with the Saints: 29-21 at Edgeley Park on 23rd September 2011.
Referee: Tim Wigglesworth
Leicester Tigers have won three of their last five matches in Aviva Premiership Rugby, and have lost just once at Welford Road since last October: 9-22 to Harlequins on 22nd September.
Bath's last six fixtures in the Premiership have all been won by the home side on the day. Bath's only away win since February in the Premiership was 24-23 at Worcester on 1st September.
Leicester's only defeat in their last nine Premiership encounters with Bath since 2008 was 25-26 at The Rec last October. Bath have won just once before at Welford Road in this competition: 13-12 on 29th November 2003.
Referee: JP Doyle
London Welsh have slipped to three straight defeats in all competitions. The Exiles' won their most recent Aviva Premiership Rugby encounter at Kassam Stadium: 16-9 over Bath on 4th November.
London Irish have lost their last three Premiership matches and have won just once on the road in the competition since September 2011: 25-16 at Worcester on 21st April.
The two teams have played just twice before in league play - way back between 1987-89 in Courage League division two with Irish winning on both occasions. London Irish have also won their only two previous cup clashes with the Welsh in 1995 and 2000.
Irish have visited Kassam Stadium twice before, losing on both occasions: 27-33 to Pontypridd in the semi-final of the Parker Pen Shield in 2002, and 9-38 to Northampton at the same stage of the Powergen Cup in 2003.
Referee: Andrew Small
Exeter Chiefs have won their last four games in all competitions and are unbeaten at Sandy Park in Aviva Premiership Rugby this season.
London Wasps last eight matches in Aviva Premiership Rugby have all been won by the home side on the day. Wasps have not won away from home in the Premiership since they visited Worcester on 28th October 2011.
The Chiefs have won their last four encounters with Wasps in all competitions, whilst the Londoners are yet to taste victory in three previous visits to Sandy Park.
Referee: Sean Davey
Saracens have slipped to back to back defeats in all competitions, whilst Sarries only Premiership defeat at Vicarage Road in their last 17 matches was 19-20 to Leicester on 19th February.
Gloucester are currently the best side in Aviva Premiership Rugby on current form having picked up 21 league points from their last six games. Gloucester's only reversal in the competition since the opening round was 25-28 to Harlequins on 3rd November.
Saracens are unbeaten in their last four encounters with Gloucester, whilst the Cherry & Whites have not been victorious at Vicarage Road since 16th November 2008.
To book tickets to our next Aviva Premiership home game against Northampton Saints, click here or call 08444 994 994 (Monday - Friday, 9am - 5pm)