Twenty-one-year-old London Wasps winger Wade and twenty-two-year-old Worcester Warriors flanker Kvesic will be making their debuts against the Pumas
Head Coach Stuart Lancaster said, "It's always a great pleasure to award someone their first caps and Christian and Matt, as well as the three uncapped players on the bench, deserve their chance against the Pumas because of their form and hard work this season for their clubs and with us.
"This is a young England side but one with a great deal of ability and self-belief that has bonded well in the time we've been together at home and in Uruguay and Argentina.
"Facing Argentina in front of their home crowd in Salta will be a challenge but I'm sure it's one this team will relish."
15. Mike Brown , 14. Christian Wade , 13. Jonathan Joseph , 12. Billy Twelvetrees , 11. David Strettle , 10. Freddie Burns , 9. Lee Dickson , 1. Joe Marler , 2. Rob Webber , 3. David Wilson , 4. Joe Launchbury , 5. Dave Attwood , 6. Tom Wood , 7. Matt Kvesic , 8. Ben Morgan
Replacements : 16. David Paice , 17. Henry Thomas , 18. Paul Doran Jones , 19. Courtney Lawes , 20. Billy Vunipola , 21. Richard Wigglesworth , 22. Kyle Eastmond , 23. Ben Foden
Latest news from Carrington.............The proposed friendly in Le Havre in August has been cancelled by the promoter today (7th June 2013)