Saints struggled in last year's Aviva Premiership curtain raiser, beating Leicester before losing to Sale and London Welsh to finish third in their group at Edgeley Park. The event at Edgeley Park was the last rugby event held there before the move to the Salford City Stadium.
Welsh's replacements next season are Newcastle, the winners of the 2011 competition, and with the top two progressing to the final at Bath the following week. Leicester Tigers are yet to make it beyond the group stage in the tournament but as the defending Aviva Premiership champions you can always expect a strong showing.
Sale Sharks meanwhile have made the finals day for the last two years in a row and will take some stopping at Franklin's Gardens.
And as the 2011 champions and fresh from their promotion back to the top-flight Dean Richards' Falcons side will be itching to kick off their return to the big time in style.