Last year Quins ran out convincing 37-12 winners at the Stoop as a combination of pace and power, saw them overcome Saracens Storm in an all-southern final.
And Quins will return to their home ground for the season's opening round of fixtures on Monday September 9 as they look to hit the ground running against Irish in the southern conference league.
Also in the same group, Saracens face a trip to Devon as they take on Exeter Braves - a team they defeated 45-30 last year - while Bath and London Wasps meet at the Recreation Ground.
Meanwhile, the Northern conference league sees Gloucester United - who lost to Quins in the semi-finals - host Worcester Cavaliers while Northampton Wanderers - who also made the semis after topping their group - visit Leicester Tigers.
The final set of opening fixtures sees Newcastle Falcons play visiting Sale Jets at Kingston Park.
Split into two leagues, with the top two in each facing each other for a spot in the final, the A League runs weekly from September until December, with this year's final taking place on Monday December 16.
Providing a platform for Premiership sides to blood their youngsters in anticipation of bringing them through to the first team, the league is known for unearthing young stars.
Man of the match in last year's final and with two tries to his name, Ollie Lindsay-Hague signed a new contract with Harlequins at the start of the year as did Darryl Mardo, Joe Trayfoot, Charlie Walker and Jack Clifford - all of whom played an integral part in their A League success last year.
And Mike Hynard, Head of Academies and Development for Premiership Rugby, believes the country is well equipped with young talent ready to strut their stuff in the league again this year.
"There is no doubt that the A League plays a huge part in the academy players' developments," he said. "It's an opportunity to play with some senior players, perhaps those coming back from injury, and to play against professional premiership rugby players.
"On the back of the England U20 win in the Junior World Championships over the summer, you can see that youth rugby in England is at an all time high.
"The challenge is for the Academies to keep producing better players year on year to improve the standard of the A League.
"The top clubs that are going well tend to do pretty well in the A League. You look at those that made the semi-finals last year, they had a lot of really talented young players on show."
Full Fixture List