Mark Cueto starts in what is his 200th appearance for Sale, another memorable moment to add to his illustrious career.
Sammy Tuitupou also starts against his ex-club.
Steve Diamond makes two changes from the side that faced Saracens, resting Rob Miller, and Andrei Ostrikov, and replacing them with Tom Arscott and Jonathan Mills.
The bench also sees three changes, with Jonathan Mills and Tom Arscott starting, and Henry Thomas being rested, and replaced by Tony Buckley.
Sale Sharks starting XV: 15. Tom Arscott 14. Tom Brady 13. Johnny Leota 12. Sammy Tuitupou 11. Mark Cueto 10. Danny Cipriani 9. Dwayne Peel 1. Eifion Lewis-Roberts 2. Marc Jones 3. Vadim Cobilas 4. Jonathan Mills 5. Michael Paterson 6. Dan Braid (C) 7. Dave Seymour 8. James Gaskell
Replacements: 16. Tommy Taylor 17. Ross Harrison 18. Tony Buckley 19. Vilami Fihaki 20. Mark Easter 21. Will Cliff 22. Nick MacLeod 23. Mark Jennings
To view the squad's formation, and the Worcester Warriors team that Sale will face on their visit to Sixways, visit the match overview on our website here