The team sees seven changes, including Henry Thomas, who replaces Vadim Cobilas - his first start since his England performances in the Six Nations.
The front row sees further changes, with Ross Harrison and Tommy Taylor replacing Eifion Lewis-Roberts and Marc Jones. Andrei Ostrikov also replaces Jonathan Mills.
There are also changes at 9 and 10 with Will Cliff and Nick MacLeod replacing first choices Dwayne Peel and Danny Cipriani.
Birthday boy Mark Jennings also replaces Sammy Tuitupou at 12, in the week he turns 21.
Sharks starting XV:
15. Tom Arscott 14. Tom Brady 13. Johnny Leota 12. Mark Jennings 11. Mark Cueto 10. Nick MacLeod 9. Will Cliff 1. Ross Harrison 2. Tommy Taylor 3. Henry Thomas 4. Andrei Ostrikov 5. Michael Paterson 6. Dan Braid (C) 7. Dave Seymour 8. James Gaskell
16. Marc Jones 17. Eifion Lewis-Roberts 18. Vadim Cobilas 19. Jonathan Mills 20. Mark Easter 21. Nathan Fowles 22. Danny Cipriani 23. Sammy Tuitupou
For the full formations, our opposition side and overview of this fixture click here.