Despite a narrow defeat to Newcastle a few weeks ago, Steve Diamond's men have impressed on their own turf, including a spirited 14-13 win over visitors Bath at the back end of last season.
Bath won just one league game away from home in their last campaign, and despite starting this season with an away win at Newcastle, faltered in their round three game against Saracens at Allianz Park, losing out 31-17.
Sharks have won three of their last four meetings between the two teams, with Bath's last victory on Sale soil coming back in 2011.
Friday's clash promises to be a tight game, and Sharks may look to their impressive display so far this season in the lineout as a way of gaining an advantage over Bath.
Michael Paterson has been in fine form, winning 26 lineout balls, with Sale having an 87% success rate on their own throw, compared to Bath's 77%.
Friday could also be a landmark day for flanker Dave Seymour. If involved, the 29 year-old will make his 100th appearance for Sale since joining in 2009.
Due to both of Bath's kits clashing with Sale's home strip, Sharks will take to the field in their away kit.