Tries from Mark Cueto and Andy Forsyth helped Sharks to a 22-16 victory Kingsholm on the opening day, as Steve Diamond's men look to prove the pre season doubters wrong.
Just one defeat in their last six games means Sale are one of the leagues form teams, with Newcastle slumping to 21-0 defeat in their curtain raiser against Bath last Friday, the first time they have failed to score at home since 1989.
The Falcons have lost just one of their last 19 games away from home in all competitions, but haven't won an away game at Sharks since 2010. This will be their first visit to Salford City Stadium.
The last encounter between the two teams ended in a 22-19 victory for Newcastle back in 2012. Despite this victory, the Falcons were unable to prevent relegation from the top tier of English rugby.
This fixture has thrown up some memorable encounters over the years, including a 19-19 draw back in 2011. The game marked the start of another spell in charge for Steve Diamond.
Another classic match was a 26-25 win for Sale in the first game of their title winning campaign. Jonny Wilkinson missed a last minute conversion to get Phillipe Saint-Andre's men off to the perfect start in a season which saw them top the Premiership table and secure victory in the final over Leicester Tigers.
Sale Sharks first home game is THIS Friday when we entertain Newcastle Falcons. Season Tickets are still available for the new season and can be booked by phoning 08444-994-994. You can also email firstname.lastname@example.org and we will call you back. Want to view the available seats at the stadium? Email email@example.com and we will arrange a convenient time for you to visit the stadium and we will show you the best available seats. You can also book match tickets for any games running up to Christmas by calling 08444-994-994.