Worcester will take confidence from the fact that the Sharks have lost on their last three visits to Sixways, despite having a run of four straight wins against Dean Ryan's men before.
Steve Diamond's men have history on their side in this competition, having lifted the trophy twice in the past, whilst Worcester have failed to win the tournament.
Victories over Pontypridd in 2002, and Pau in 2005 (both played at the Kassam Stadium in Oxford) gave Sale the platform to help them win the Premiership title just a few years later.
Sharks breezed past the other French club in the group Biarritz with a convincing 33-10 victory at the AJ Bell stadium. Joe Ford heavily impressed, scoring 16 points on the way to Sale's victory.
Sale have scored 268 tries in all of their previous games in the competition, as opposed to Worcester's 244.
Sale Sharks next home game is on Friday 1st November 2013 at the AJ Bell Stadium when they entertain the free scoring Exeter Chiefs in the Aviva Premiership, kick off 8pm. Tickets are available online at http://www.salesharks.com/tickets/individual.php . You can also book by phoning 08444-994-994 or request a ringback by emailing firstname.lastname@example.org.