The Sharks will head down to London to play at Allianz Park for the first time, and will be buoyed by the fact that they have beaten Saturday's opponents twice in their last three outings.
Thomas, who is out injured with damaged rib cartilage, said: "In the end it comes down to 15vs15 and with the talent we've got in our squad we back ourselves to beat anyone on the day."
"They're always going to be one of the top teams because their squad is full of internationals and they've got a lot of players to choose from who are all very talented, but we know we're good enough to beat them," he added.
Sale's opponents for this weekend's game boast several star names, including Chris Ashton and the Vunipola brothers, with the team widely regarded as the best in the Aviva Premiership, but Thomas believes The Sharks are more than good enough to cause an upset.
"When you play them it's always going to be a challenge because they are top quality. We play against top player's week in week out so we don't see them as any better or worse than the other teams."
Sale will be looking to build on last week's success over bottom club Worcester, as their impressive home form continued in style with a bonus point win.
Despite securing just one win away from home in three attempts this season in the league, Thomas, who was recently called up to Stuart Lancaster's England squad, doesn't see any reason why The Sharks can't win at Allianz Park.
"You have to be realistic going into every away game, but also go there with a real belief that you are good enough. Our target in most away games is a losing bonus point as the absolute minimum, so there's no way we'll go down to Sarries without thinking we can win the game."
SALE SHARKS NEXT HOME GAME IS ON FRIDAY 13TH DECEMBER WHEN THEY ENTERTAIN OYONNAX IN THE AMLIN CHALLENGE CUP. TICKETS ARE AVAILABLE BY PHONING 08444-994-994. YOU CAN REQUEST A CALLBACK BY EMAILING firstname.lastname@example.org .