Although Sharks are currently sitting at the top of Pool Two, only a bonus point win would completely guarantee a Semi Final place. A win would put Sharks in the mix along with Exeter Chiefs and Leicester Tigers, but defeat would almost certainly mean Sale would be eliminated from the competition.
With three sides having booked their semi-final place, four teams still have it all to play for in Round 4, with one spot still remaining in the knockout stages.
Sale Sharks join Exeter Chiefs, Leicester Tigers and Cardiff Blues as contenders to qualify as one of the four sides who could still qualify from the highly competitive Pool 2. The Welsh outfit are the outside runners for the final spot, needing to claim five points from their Friday night clash with reigning champions Harlequins and hope that all three of their rivals fail to pick up a point in the final round to have any chance of progressing.
If Sale record a bonus-point win against Ospreys at the Liberty Stadium on Friday night they will be guaranteed to join Saracens, Bath and Northampton Saints in the semi-finals. Ospreys won 17-16 when these sides last played each other at the Liberty Stadium, Shane Williams' injury-time try, converted by James Hook, securing victory in a nail-biting Heineken Cup tie on October 20, 2006.
Steve Diamond has named his team:
1 - Aston Croall 2 - Dan Baines 3 - Tony Buckley
4 - Jonathan Mills 5 - Tom Holmes
6 - Mark Easter (C) 8 - Villami Fihaki 7 - Andy Hughes
9 - Will Cliff 10 - Joe Ford
11 - Charlie Ingall 12 - Mark Jennings 13 - Andy Forsyth 14 - Phil MacKenzie
15 - Mike Haley
Marc Jones, Ross Harrison, Vadim Cobilas, James Gaskell,
David Seymour, Nathan Fowles, Nick Macleod, Tom Arscott