Steve Diamond's men also ran out 26-10 winners when the two sides met in the Premiership back in November, and James Gaskell, who scored the first try in that victory, admitted that despite Warriors' league position, it will be a tough match.
"No games are easy nowadays, but this is a great chance for us to push on. It's obviously huge for them, we were in that situation last year where it got to the point that we had to win every game, and they're going to scrap for everything.
"They have played some good rugby in the past two weeks, a lot of which is based on hard work and commitment, which brings a physical edge to their approach."
Despite losing their last 19 league matches, Dean Ryan's beleaguered squad were unfortunate not to record a big upset when they narrowly lost 22-23 to Leicester a few weeks ago.
Gaskell was quick to point out the potential danger men in the Worcester squad: "Their pack is obviously a big threat, but the back three is also lethal. Names like (David) Lemi and (Chris) Pennell are names that have been feared around the Premiership for years now, so it will be a big test.
"When they run a team like Leicester who were almost full strength all the way, and lose by just one point, you know it is going to be a tough one."
Sharks' fantastic season almost got even better last Friday, when they lost out 15-10 to Saracens, despite scoring the only try of the game and playing some terrific rugby.
Worcester have only managed to score more than a single try in one game so far during this campaign, though Gaskell did point out that it won't be easy to secure more Premiership points with so much expectation for them to do so.
"We still want to beat one of the top four teams, which is what we are working towards, but it's a completely different challenge this weekend where everybody is assuming that we are going to win.
"The lads have played well against pretty much every team this year, which is proving to everyone that we can challenge for the playoffs."