The Game Changer rewards the player responsible for the most effective single performance each month, according to the Opta statistics.
Paterson's Sale side made light work of their trip to Sandy Park, registering eight tries in a commanding 55-12 win.
In attack, Paterson touched down for a try in addition to making 60 meters from 18 carries, beating eight defenders along the way. The lock was equally strong in defence, making eight tackles across the 80 minutes.
Paterson said: "The team have traditionally found it tough at Exeter so to come away with such a positive result is really pleasing.
Each of the monthly Game Changer winners will be competing for the Game Changer of the Season Award which is announced in May. Last year's big prize was won by Harlequins' Ollie Lindsay Hague.
Michael Paterson is also nominated for Green Flag's Forward of the Season Award. After a terrific season, it is great to see Pato getting the recognition he deserves.
The G-Series Pro products from Gatorade are now available online at www.gatoradestore.co.uk
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