Sharks won the home fixture 15-3 at the AJ Bell Stadium just before Christmas and the players will be looking to finish on a high.
The Madesjki Stadium has not been a happy hunting ground for Sale over the past few years and the last victory there came back in October 2006. The hosts have not enjoyed the best of seasons and have only won 2 of their last 7 premiership games at the stadium.
On their last visit to London Irish, Sharks gained a very creditable draw (33-33) and gained three points in doing so; two game points and a try bonus. Nick Macleod kicked a last minute penalty.
Referee for Saturday afternoon's game is Greg Macdonald who is officiating in his first ever Aviva Premiership fixture.
Sale Sharks season tickets for 2014-2015 continue to sell well and fans are reminded that the early bird discount ends at close of business, tomorrow, Friday 9th May.
To book your place for next season please call 08444 994 994. For a call back please email firstname.lastname@example.org.