Both Henry Thomas and James Gaskell start in what will be their last game in a Sharks shirt.
The team sees six changes to the one that faced Leicester Tigers last Saturday at the AJ Bell Stadium. This includes a complete change to the front row, with Ross Harrison, Tommy Taylor and Henry Thomas in for Eifion Lewis-Roberts, Marc Jones and Vadim Cobilas.
Elsewhere, neither Dwayne Peel or Danny Cipriani feature in the travelling squad, with Will Cliff and Joe Ford taking up their places in the starting line-up respectively.
Mark Easter takes up Viliami Fihaki's spot, who starts the game on the bench, and Dave Seymour continues his skipper role in place of injured captain Dan Braid.
15 - Tom Arscott, 14 - Tom Brady, 13 - Jonny Leota, 12 - Sammy Tuitupou, 11 - Charlie Ingall, 10 - Joe Ford, 9 - Will Cliff
1 - Ross Harrison, 2 - Tommy Taylor, 3 - Henry Thomas, 4 - Andrei Ostrikov, 5 - Michael Paterson, 6 - Mark Easter, 7 - David Seymour (C), 8 - James Gaskell
16 - Marc Jones, 17 - Eifion Lewis Roberts, 18 - Vadim Cobilas, 19 - Kirill Kulemin, 20 - Viliami Fahiki, 21 - Nathan Fowles, 22 - Nick Macleod, 23 - Mark Jennings
For the full match overview, including stats about previous fixtures and the formation click here