Flanker James Doyle is set to make his senior debut for the club. Doyle (21) joined the Sharks from Leicester Tigers during the Summer. Scrum half Nathan Fowles (19) will make his first appearance in the Aviva Premiership if he comes off the bench. Fowles, a used replacement in the club's Amlin Challenge Cup game at C.R.La Vila last January, comes from Rochdale and gained experience with Preston Grasshoppers last season.
Will Addison returns to the squad after a two game absence, whilst Dwayne Peel, Richie Gray and Henry Thomas are ruled out through injury.
Sale Sharks: 15.Rob Miller, 14.Tom Brady, 13.Johnny Leota, 12.Sam Tuitupou, 11.Mark Cueto, 10.Nick Macleod, 9.Cillian Willis, 1.Eifion Lewis-Roberts, 2.Tommy Taylor, 3.Tony Buckley, 4.Fraser McKenzie, 5.Kearnan Myall, 6.James Doyle, 7.David Seymour (capt.), 8.Andy Powell
Replacements: 16.Joe Ward, 17.Vadim Cobilas, 18.Aston Croall, 19.James Gaskell, 20.Mark Easter, 21.Nathan Fowles, 22.Danny Cipriani, 23.Will Addison
Sharks' Director of Rugby Bryan Redpath said, "There are opportunities for some of the younger boys in the club. It's been tough after last Friday's match and what followed at the weekend. We're desperate to get another game under our belt because some of the parts of last week's match weren't what we expected.
"James Doyle and Nathan Fowles are two young members of the group. James has played exceptionally well for the Jets. He's come in and worked really hard to put pressure on others at the club. They both need to go out and enjoy the game as much as they can.
"Last season, Sale Sharks went to Bath on the back of a disappointing home performance and won, later going on to complete a double. As I've said, last week was unacceptable and hopefully we can show a big improvement."
Olly Barkley will start his final game for Bath Rugby at fly-half. Barkley, leaving to join Top 14 side Racing Metro 92, has made over 230 appearances in the Blue, Black and White, and scored over 2160 points in his time at the Club.
He re-joins Michael Claassens at half back, with Stephen Donald switching to inside centre.
Bath Rugby: 15.Nick Abendanon, 14.Kyle Eastmond, 13.Dan Hipkiss, 12.Stephen Donald, 11.Tom Biggs, 10.Olly Barkley, 9.Michael Claassens, 1.Paul James, 2.Lee Mears, 3.David Wilson, 4.Stuart Hooper (capt.), 5.Dave Attwood, 6. Carl Fearns, 7.Ben Skirving, 8.Simon Taylor
Replacements: 16.Ross Batty, 17.Nathan Catt, 18.Anthony Perenise, 19. Dominic Day, 20.Will Skuse, 21.Mark McMillan, 22.Sam Vesty, 23.Jack Cuthbert
Referee: Sean Davey
Follow the action as it happens on @SaleSharksRugby Twitter.
Ticket news for this game at Bath here.