England Under-20 international prop Ross Harrison makes his first start, although he has made six replacement appearances since his first outing at La Vila last January.
Sale Sharks: 15.Nick Macleod, 14.Tom Brady, 13.Johnny Leota, 12.Sam Tuitupou, 11.Mark Cueto, 10.Danny Cipriani, 9.Cillian Willis, 1.Ross Harrison, 2.Tommy Taylor, 3.Tony Buckley, 4.Richie Gray, 5.Fraser McKenzie, 6.Richie Vernon, 7.David Seymour (capt.), 8.Andy Powell
Replacements: 16.Joe Ward, 17.Eifion Lewis-Roberts, 18.Vadim Cobilas, 19.Kearnan Myall, 20.James Gaskell, 21.Nathan Fowles, 22.Rob Miller, 23.Will Addison
Sharks' Director of Rugby Bryan Redpath said, "It's a massive match for us, and for Worcester as well. They'll be looking for a big performance after two high scoring wins in the Amlin Challenge Cup and we had a great result against Cardiff, followed by a tough match at Montpellier.
"We've got make sure that we're focused on the game, not on the table. Our emphasis is to be very disciplined and be clear about our game plan. Away matches like this are tough, and Friday evening will be a massive challenge for us."
Former Sharks Chris Jones and Dean Schofield are on the Warriors bench, with loosehead prop Matt Mullan skippering the side.
Worcester Warriors: 15.Chris Pennell, 14.Errie Claassens, 13.Alex Grove, 12.Josh Matavesi, 11.David Lemi, 10.Andy Goode, 9.Paul Hodgson, 1.Matt Mullan (capt.), 2.Aleki Lutui, 3.John Andress, 4.James Percival, 5.Craig Gillies, 6.Sam Betty, 7.Matt Kvesic, 8.Semisi Taulava
Replacements: 16. Ed Shervington, 17.Ceri Jones, 18.James Currie, 19.Dean Schofield, 20.Chris Jones, 21.Jonny Arr, 22.Joe Carlisle, 23.Ravai Fatiaki
Referee: Greg Garner
Tickets for the match remain on sale from the Warriors Box Office on 01905 454183 or by clicking online at www.warriors.co.uk
Sale Sharks advise their travelling supporters to allow plenty of time. There are roadworks and a speed limit on the M.5 just before Sixways.
The game is not being televised live, but you can keep up with events as they happen on @salesharksrugby Twitter #WARvSHA
A considered report will appear on this website's home page around 11.00pm.