Cardiff are enduring a long losing run in the Heineken Cup having lost their last six games.
This will be the sixth meeting between the sides in the Heineken Cup with the home side winning every game. Earlier this season, Sharks looked out of it at half time but an inspired performance by substitute Danny Cipriani saw Sharks win 34-33.
The game at Cardiff Arms Park kicks off at 3-40pm as both games in the group have to kick off at the same time as per Heineken regulations. Whoever wins the game in Cardiff will escape finishing bottom of the group.
Cardiff Blues are working on their ground and are confident that the game will go ahead. The Cardiff City Football Stadium, which is only 1 mile from Cardiff Arms Park and has under-soil heating, will be use as an alternative if needed.
A win would mean the Welsh region keeping their place in the top six of the tournament's seedings for next season's draw.
Sale Sharks: 15 Cameron Shepherd, 14 Tom Brady, 13 Jordan Davies, 12 Mark Jennings, 11 Charlie Amesbury, 10 Rob Miller, 9 Will Cliff, 1 Aston Croall, 2 Tommy Taylor, 3 Vadim Cobilas, 4 Tom Holmes, 5 Kearnan Myall, 6 James Doyle, 7 David Seymour (Capt), 8 Richie Vernon
Replacements: 16 Marc Jones, 17 Ross Harrison, 18 Eifion Lewis Roberts, 19 Richie Gray, 20 Tom Cruse, 21 Nathan Fowles, 22 Danny Cipriani, 23 Mark Cueto
The next home match for the Sharks will be Sale Sharks v Scarlets on Saturday 26th January in the LV Cup. Tickets are available now and can be booked online or by calling 08444 994 994.