Cameron Shepherd comes in as a late change for Rob Miller who has failed a fitness test.
The forwards sees Richie Gray back in the starting line up after playing in Scotland's opening two RBS Six Nations games and Andy Powell is named amongst the replacements following his recovery from a hand injury.
Team: 15 Cameron Shepherd, 14 Charlie Amesbury, 13 Jonny Leota, 12 Sammy Tuitupou, 11 Mark Cueto, 10 Danny Cipriani, 9 Will Cliff, 1 Alasdair Dickinson, 2 Marc Jones, 3 Henry Thomas, 4 Richie Gray, 5 Tom Holmes, 6 Dan Braid, 7 David Seymour, 8 James Gaskell
Replacements 16 Tommy Taylor, 17 Ross Harrison, 18 Eifion Lewis Roberts, 19 Andy Powell, 20 Richie Vernon, 21 Cillian Willis, 22 Nick Macleod, 23 Will Addison
London Welsh head coach Lyn Jones makes four changes for Sunday's game.
Gavin Henson and Alex Davies form a new half back combination, with Gordon Ross and Tyson Keats named among the replacements.
In the forwards, Paulica Ion comes in at tight head for Greg Batman, while there's a debut for new signing Argentina international Julio Cabello, who starts at openside in place of Michael Hills.
London Welsh: 15. Tom Arscott, 14. Phil MacKenzie*, 13. Gonzalo Tiesi*, 12. Sonny Parker*, 11. Nick Scott, 10. Gavin Henson*, 9. Alex Davies, 1. Franck Montanella*, 2. Neil Briggs, 3. Paulica Ion*, 4. Jonathan Mills (C), 5. Matt Corker, 6. Adam Balding, 7. Julio Cabello*, 8. Ed Jackson.
Replacements: 16. Greg Bateman, 17. Tom Bristow, 18. James Tideswell, 19. Kirill Kulemin*, 20. Michael Hills, 21. Tyson Keats, 22. Gordon Ross*, 23. Seb Jewell.
Sale Sharks next home game is against Harlequins on Friday 22nd February Kick Off 8pm. Tickets are available by phoning 08444-994-994 or online at http://www.salesharks.com/tickets/index.php