Since then Sharks have been to Wasps and inflicted their first defeat at Adams Park this season and added the scalps of Exeter Chiefs and London Welsh.
Harlequins however are probably the toughest test yet. They are reigning Aviva Premiership Champions and have won their last five away games. Their last defeat away from the Stoop was last November when they lost 18-21 to Bath at The Rec.
Sale lost heavily at the Stoop back in September (14-37) and the last time Sharks beat Quins was back in September 2010 with a 21-17 win at Edgeley Park.
Referee for the game on Friday is Martin Fox who will be officiating at his 85thPremiership game and he will be assisted by Robin Goodliffe and Gareth Copsey.
Quins showed just what they are capable of with a 25-21 win over Leicester Tigers at the Stoop last week with young Ben Botica kicking 6 penalties and a conversion. Botica was a last minute replacement for Nick Evans who pulled up in the pre match warm up.
Team Cameron Shepherd , Charlie Amesbury, Jonny Leota, Sammy Tuitupou, Mark Cueto, Danny Cipriani, Will Cliff, Ross Harrison, Tommy Taylor, Henry Thomas, Fraser Mckenzie, Kearnan Myall, Dan Braid, David Seymour Captain, James Gaskell
Replacements Marc Jones, Eifion Lewis-Roberts, Tony Buckley, Tom Holmes, Richie Vernon, Cillian Willis, Nick Macleod, Will Addison
Tickets are available by phoning 08444-994-994 or online at http://www.salesharks.com/tickets/index.php