Both sides won last weekend, Irish beat Worcester convincingly and Sale beat Bath thanks to a late Tom Brady try.
Irish have put a run of form together of late in the Aviva Premiership at home and their last defeat at 'The Mad Stad' was at home to Leicester Tigers just before Christmas.
Sharks won the game at Salford back in November by 21 points to 9 with Nick Macleod and Jonny Leota scoring tries. That win was Sharks first of the season in the Premiership.
Team Cameron Shepherd, Charlie Amesbury, Johnny Leota, Sam Tuitupou, Mark Cueto, Nick Macleod, Dwayne Peel, Alasdair Dickinson, Marc Jones, Henry Thomas, Kearnan Myall, Andrei Ostrikov, Daniel Braid, David Seymour Captain, James Gaskell
Replacements Tommy Taylor, Ross Harrison, Tony Buckley, Tom Holmes, Andy Powell, Nathan Fowles, Danny Cipriani, Tom Brady
READING RAILWAY STATION ENGINEERING WORKS
There are restricted rail services into Reading Station:
One train per hour from routes Basingstoke / Newbury but a half hourly service from London Waterloo via Richmond and Wokingham
No trains into Reading from Paddington or Didcot
Rail replacement bus services
Didcot to Reading Old Bus Station - 2 services - one direct and one stopping at all stations.
Maidenhead to Reading Old Bus Station - via Twyford