Two penalty tries, a score from Andrei Ostrikov and a 100% kicking record from Joe Ford led the Sharks to their first ever win against their French opponents.
Biarritz brought with them a squad boasting eight internationally capped players, but were unable to overhaul a Sale side high on confidence after an excellent start to the season.
The Sharks came into the game on the back of strong home win against Bath, and were quick out of the blocks as they forced a penalty from a scrum four minutes in.
Joe Ford, making his first start in a Sale shirt, slotted over the three points as Steve Diamond's men looked to assert their dominance early on.
Biarritz started the game on the back of a poor run of results in France's Top 14, as they sat bottom with just one win in nine games.
Despite this, Veteran skipper Julien Peyrelongue hit back for the visitors soon after Sale's opener, as their first venture into the Sharks half produced a penalty to level the scores.
Ford added to his tally just three minutes later with an opportunistic drop goal to put the Sharks back in front.
Sam Tuitupou and Johnny Leota were back together as Sale's centre partnership, and were both back to their best with a terrific show of ferocious tackling and industrious attacking play.
Impressive play by the Sharks at scrum time was again in evidence as Ford was awarded an opportunity to extend Sale's lead once more from a terrific Sale drive. Ford's fabulous hit from 42 metres out created a 6 point gap midway through the first half.
Mark Easter's powerful charge toward the Biarritz line almost set the game alight as he quickly picked up the ball from a ruck to charge through, only to drop the ball as the try line beckoned.
It nearly didn't matter, as Ford had a try disallowed by the TMO moments later after attempting to touch down after Jo Pietersen had thrown the ball behind his own line in an attempt to keep play alive.
The action didn't stop there as from the resulting scrum the Sharks were awarded a penalty try, as their continuous pressure finally proved too much for the visitors. Ford's conversion put Sale firmly in the driving seat with a 16-3 lead after 26 minutes.
As well as the Sharks had done in an attacking sense, their defending was also up to scratch as Rob Miller thwarted Biarritz scrum half Yann Lesgourgues, after his chip in behind looked to exploit the hosts.
Half Time: Sale 16-3 Biarritz
Sale started the second half in the same way they had started the first, with Ford adding to his tally once again with a simple penalty from 20 metres out after 46 minutes.
If anyone in the ground thought that the Sharks would then begin to sit back on their lead, they were soon proved wrong as Andrei Ostrikov powerfully charged through a gap in the Biarritz defence to score Sale's second of the evening. Ford successfully added the two points.
In one of their first excursions into the Sharks territory after the break, Biarritz successfully drove themselves over the Sale line as Eugene Van Staden gave the French side a glimmer of hope just before the hour mark. Peyrelongue's conversion cut the deficit to 16 points.
Danny Cipriani entered the fray on the hour mark, as Ford left the field with a perfect kicking record on the night. The 23 year-old, who was signed from Leeds Carnegie in the summer, was rightly applauded off after a fantastic display.
Sale's continued pressure at the scrum eventually forced a sin bin for Biarritz replacement Francisco Gomez, who left his side with 14 players as the Sharks camped out on their opponent's line.
A series of five metre lineout's for Sale failed result in a try as the game went into the last ten minutes and Diamond began to ring the changes.
Sharks were then awarded their second penalty try of the game as Biarritz's scrum creaked once again to give referee Ian Davies no option but to punish the visitors again.
Sale were rightly cheered off at the end as they recorded their first win of their European campaign, and will now look towards a trip to Premiership strugglers Worcester in their next Pool A game.
Sale: Rob Miller; Phil MacKenzie (off 72mins), Johnny Leota, Sam Tuitupou, Tom Brady; Joe Ford (off 60mins), Will Cliff (off 69mins); Ross Harrison (off 74mins), Marc Jones (off 70mins), Henry Thomas (off 70mins), Kirill Kulemin (off 69mins), Andrei Ostrikov, Jonathan Mills, Dan Braid (off 74mins), Mark Easter.
Replacements: Tommy Taylor (on for Jones 71mins), Aston Croall (on for Harrison 74mins), Vadim Cobilas (on for Thomas 71mins), Tom Holmes (on for Kulemin 69mins), Andy Hughes (on for Braid 74mins), Nathan Fowles (on for Cliff 69mins), Danny Cipriani (on for Ford 60mins), Tom Arscott (on for MacKenzie 72mins)
Scoring Sequence (Sharks first): 3-0, 3-3, 6-3, 9-3, 14-3, 16-3 (Half Time) 19-3, 24-3, 26-3, 26-8, 26-10, 31-10, 33-10
|Sale Sharks Score Card|
|Biarritz Olympique Pays Basque Score Card|
|Eugene van Staden||1||5|