Katy Daley-Mclean makes five changes to her starting XV that faced Wasps as a host of Scottish internationals return on the bench
US Eagle Joanna Kitlinski earns her first start at hooker since joining the club as Sharks prepare for a visit to league-leaders Saracens Women.
She is propped either side by fellow Eagles Catie Benson and Nick James, captain, making up and all-American front-row.
Katie Houghton replaces Anya Richmond in the second-row and is joined in the engine room by former-Saracen Molly Morrissey as Sharks look to continue their recent success at scrum-time.
Behind an unchanged backrow, Jess Roberts earns a start at scrum-half after a searing performance off the bench last weekend. She pairs with Lizzie Duffy at fly-half.
The other two changes for Sharks come in the back-three, with Evie Tonkin replacing Lauren Delany on the right, and Rachel Woosey donning the number-15 to start at full-back.
On the bench, Sarah Law, Lisa Thomson, and Rachel McLachlan are all named, freshly returned from World Cup-qualifying victory with Scotland Rugby.
15. Rachel Woosey, 14. Evie Tonkin, 13. Hollie Bawden, 12. Katana Howard, 11. Jodie Ounsley, 10. Lizzie Duffy, 9. Jess Roberts; 1. Catie Benson, 2. Joanna Kitlinski, 3. Nick James (C), 4. Molly Morrissey, 5. Katie Houghton, 6. Vicky E Irwin, 7. Lucy Winter, 8. Daisy Hibbert-Jones
16. Molly Kelly, 17. Gwenllian Pyrs, 18. Leah Lyons, 19. Amy Orrow, 20. Rachel McLachlan, 21. Mhairi Grieve, 22. Sarah Law, 23. Lisa Thomson